Rapebrazole is widely used to heal and prevent gastrointestinal (stomach and guts) disorders, which are caused due to abundance of stomach acid. It is a proton pump inhibitor (PPI) that is famed as an ulcer healing medicate and is much beneficial for curbing secretion and gastric from the stomach. It treats several acid related gastrointestinal states as well as cures stomach and intestinal ulcers. Managing gastro-oesophageal reflux disease (GORD) that is a condition in which acid makes a growth from the stomach into the esophagus with prodrome of acid regurgitation, heartburn and pain on swallowing.
Domperidone is a dopamine resister that comes with anti-emetic properties. Its anti-emetic effects occurs due to the accumulation of peripheral (gastrokinetic) effects and opposition of dopamine receptors in the chemoreceptor trigger area that lies in the external the blood-brain barrier in the orbit named as postrema. Domperidone increases reduced esophaegeal pressure and improves the antroduodenal motion by accelerating gastric evacuation with no issue in gastric secretion.
Principle for Combination:
Rabeprazole being the quickest acting PPI affords a fast relief from the hyper acid secretory states.
Domperidone as an anti-emetic amends the LES tone and enhances the gastric motility. The GERD patients who are not responding to Rabeprazole alone, gets the benefit from the combination of Rabeprazole and Domperidone.
Indications and Usages: